Background:
Probiotic therapy in the form of food formulations is a natural and cost-effective strategy for gut health. At NDRI, our group was the first to focus on indigenous strains of probiotic lactobacilli of Indian gut origin. Amongst these, one of the strains belongs to Lactobacillus fermented Lf1 whose identity has also been established by molecular tools using 16S rRNA (accession no. KC509914) and rpoA (accession no. KC509912). The draft Genome Sequence of Lactobacillus fermentum Strain Lf1 has been submitted to DDBJ/EMBL/GenBank under the accession no. AWXS00000000. It has been deposited in the International Depository Budapest Treaty at the Microbial Type Culture Collection (MTCC) as strain MTCC 5689. Lf1 possesses probiotic attributes, viz. acid and bile tolerance and cell surface properties like cell surface hydrophobicity, aggregation and co-aggregation abilities besides exhibiting inhibitory action against gastrointestinal pathogens. The functional efficacy of Lf1 in terms of its anti-inflammatory and anti-oxidative properties was demonstrated in a dextran sodium sulfate (DSS)-induced colitis mouse model. Besides Lf1 exhibited anti-diabetic potential with improved glucose tolerance and insulin sensitivity in high-fat diet-fed C57BL/6J mice. The strain has been tested for safety both in in-vitro and in vivo animal models. As a scientifically established probiotic strain. L. fermentum Lf1 is an ideal candidate probiotic for developing probiotic fermented dairy products and in the form of food supplements as powders and sachets for effective management of health care and wellbeing in today’s scenario when consumer is looking for foods for nutrition and well- being to cut down on medicine
Technology Details:
As a scientifically established probiotic strain. L. fermentum Lf1 is an ideal candidate probiotic for developing probiotic fermented dairy products and in the form of food supplements as powders and sachets for effective management of health care and well-being (L. fermentum is listed in the schedule VII (List of strains as probiotics) in the Standards of Health supplements and Nutraceuticals) in today’s scenario when consumer is looking for foods for nutrition and well-being to cut down on medicine.